Ketamine
Ketamine
Ketamine is a dissociative anaesthetic used medically and recreationally. It acts as an NMDA receptor antagonist, producing dissociation, analgesia, and at higher doses a state known as the k-hole — a profound dissociative experience.
effects
- Dissociation from body and environment
- Visual and perceptual distortions
- Pain relief and anaesthesia
- K-hole at high doses — complete disconnection from reality
- Impaired motor function
- Antidepressant effects at sub-anaesthetic doses
harm reduction
- Never use alone — risk of injury during dissociation
- Avoid combining with alcohol, GHB, or other depressants
- Bladder damage occurs with heavy frequent use — take extended breaks
- Don't redose until previous dose is fully assessed
- Set up a safe comfortable space before using
- Addiction potential is real with regular use
combination safety
GHB
dangerous, extreme respiratory depression risk
Alcohol
both CNS depressants, blackout risk
Opioids
respiratory depression risk
Cannabis
intensifies dissociation significantly
external sources
related substances
Ask the Psychnosis AI anything about Ketamine — effects, dosages, harm reduction, combinations, experiences, pharmacology.
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This information is for harm reduction purposes only. Always research substances thoroughly before use. Psychnosis does not encourage drug use. If you are struggling with substance use, please seek professional support.